Exogenous interleukin-10 alleviates allergic inflammation but inhibits local interleukin-10 expression in a mouse allergic rhinitis model
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interleukin-25 enhances allergic inflammation through p38mapk and nf-κb pathways in mouse models of allergic rhinitis.
interleukin (il)-25, a cytokine of il-17 family, can activate p38 mitogen-activated protein kinases(mapk) and nuclear factor(nf)-κb pathways to propagate th2 responses. the allergic rhinitis mouse model was established by stimulating balb/c mouse with ovalbumin (ova). then we detected expression of il-25 and downstream p38mapk and nf-κb. the expression of il-25, p38mapk and nf-κb were detected ...
متن کاملGene polymorphisms of interleukin-10 and transforming growth factor beta in allergic rhinitis.
BACKGROUND Allergic rhinitis (AR) is a polygenic inflammatory disorder of the upper respiratory airway with an increasing prevalence worldwide. Interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), as two cytokines with pleiotropic effects on both innate and adaptive immunity, play important roles in allergic responses. Therefore, this study was performed to evaluate the associati...
متن کاملInterleukin-25 Enhances Allergic Inflammation through p38MAPK and NF-κB Pathways in Mouse Models of Allergic Rhinitis.
Interleukin (IL)-25, a cytokine of IL-17 family, can activate p38 Mitogen-Activated Protein kinases(MAPK) and Nuclear Factor(NF)-κB pathways to propagate Th2 responses. The allergic rhinitis mouse model was established by stimulating BALB/c mouse with ovalbumin (OVA). Then we detected expression of IL-25 and downstream p38MAPK and NF-κB. The expression of IL-25, p38MAPK and NF-κB were detected ...
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Interleukin (IL)-17A is a major cytokine produced by Th17 cells, which are associated with chronic inflammations. The local expression of IL-17A in allergic rhinitis (AR) remains to be characterized. We sought to determine the role of IL-17A expression in human inferior turbinate mucosa in the pathophysiology of AR. Inferior turbinate mucosa was sampled from medical treatment-resistant, surgery...
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ژورنال
عنوان ژورنال: BMC Immunology
سال: 2014
ISSN: 1471-2172
DOI: 10.1186/1471-2172-15-9